Biological Cell Four-wave Interferometric Sensor

Our Biological Cell Four-wave Interferometric Sensor harnesses the powerful capabilities of four-wave interference to provide high-resolution imaging and analysis, enabling researchers and medical professionals to gain an unprecedented level of insight into cell morphology, dynamics, and interactions. This cutting-edge technology is expected to revolutionize the way we study and understand biological cells, offering new possibilities for the advancement of life sciences. BOJIONG Optoelectronics is eager to collaborate with researchers, academic institutions, and healthcare professionals worldwide to explore the full potential of our Biological Cell Four-wave Interferometric Sensor. Together, we can open up new frontiers in biological research and contribute to the progress of medical science.

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Product Description

The plug-and-play Biological Cell Four-wave Interferometric Sensor supports near-infrared and LED white light spectrum illumination. The imaging process does not require labeling or staining, and is capable of achieving in vivo 3D imaging at a rate of up to 24 frames per second. It can quickly be used in conjunction with any optical microscope to provide real-time measurements of the 3D phase distribution of the measured cells. It is capable of assessing cell volume and weighing. This sensor from BOJIONG is an ideal tool for label-free 3D live cell detection, biological tissue detection, germ cell detection, and micro/nano structure detection.

Item Specification

Product name	Biological Cell Four-wave Interferometric Sensor
Wavelength range	400nm~1100nm
Target size	7.07mm×7.07mm
Spatial resolution	23.6μm
Image pixel	2048×2048
Phase output resolution	300×300（90000pixel）
Phase resolution	＜2nmRMS
Absolute accuracy	10nmRMS
Dynamic range	110μm（150λ）
Sampling rate	24fps
Real-time processing speed	10Hz（At full resolution）
Interface type	GIGE
External interface	Cport
Size	56.5mm×43mm×41.5mm
Weight	about 120g

Feature Of BOJIONG Biological Cell Four-wave Interferometric Sensor

◆Label-free 3D live cell imaging

◆Single-channel light self-interference, no reference light required

◆Compact size, plug and play

◆Suitable for all optical microscope upgrades and extensions

◆Broad spectrum 400nm~1100nm band

◆Extremely strong anti-vibration performance, no need for optical vibration isolation

◆Supports LED white light and short-wave infrared light source

Application Of BOJIONG Biological Cell Four-wave Interferometric Sensor

This BOJIONG Biological Cell Four-wave Interferometric Sensor used in labeling free 3D living cell detection, biological tissue detection, germ cell detection, micro and nano structure detection.

Unmarked 3D live cell detection optical path detection optical path

3D Living cell microscope - Sample measurement of roundworm eggs

Sample measurement of ovarian granulosa cell tumor

Sample measurement through micro - nano structure

BOJIONG Biological Cell Four-wave Interferometric Sensor Details

BOJIONG Biological Cell Four-wave Interferometric Sensor developed by a team of professors from Zhejiang University and Nanyang Technological University of Singapore, utilizes domestic patented technology and combines diffraction and interference to achieve common four-wave transverse shear interference. This sensor boasts superior detection sensitivity and anti-vibration performance, enabling real-time and high-speed dynamic interferometry without the need for vibration isolation. Real-time measurements show a frame rate exceeding 10 frames per second. Additionally, the FIS4 sensor features an ultra-high phase resolution of 512×512 (260,000 phase points), with a measurement band covering 200nm to 15μm, measurement sensitivity reaching 2nm, and measurement repeatability better than 1/1000λ (RMS). It is applicable for laser beam quality analysis, plasma flow field detection, real-time measurement of high-speed flow field distribution, optical system image quality evaluation, microscopic profile measurement, and quantitative phase imaging of biological cells.

FIS4 Technical parameters of each series of products

Product	FIS4-UV	FIS4-HR	FIS4-UHR	FIS4-HS	FIS4-Cell	FIS4-NIR
Wavelength range	200~450nm	400~1100nm	400~1100nm	400~1100nm	400~1100nm	900~1200nm
Target size mm²	13.3×13.3	7.07×7.07	13.3×13.3	10.24×10.24	7.07×7.07	13.3×13.3
Spatial resolution	26μm	23.6μm	26μm	24.4μm	23.6μm	26μm
Image pixel	-	2048×2048	-	-	2048×2048	-
Phase output resolution	512×512 （262144pixel）	300×300（90000pixel）	512×512（262144pixel）	420×420（176400pixel）	300×300（90000pixel）	512×512（262144pixel）
Phase resolution	＜2nmRMS	＜2nmRMS	＜2nmRMS	＜2nmRMS	＜2nmRMS	＜2nmRMS
Absolute accuracy	10nmRMS	10nmRMS	15nmRMS	10nmRMS	10nmRMS	15nmRMS
Dynamic range	90μm （256λ）	110μm （150λ）	162μm （256λ）	132μm （210λ）	110μm （150λ）	270μm （256λ）
Sampling rate	32fps	24fps	45fps	107fps	24fps	45fps
Real-time processing speed	10Hz (Full resolution)	10Hz (Full resolution)	10Hz (Full resolution)	10Hz (Full resolution)Supports delayed batch processing	10Hz (Full resolution)	10Hz (Full resolution)
Interface type	USB3.0	GIGE	USB3.0	GIGE	GIGE	USB3.0
External interface	-	-	-	-	C port	-
Size mm²	70x46.5x68.5	56.5x43x41.5	70x46.5x68.5	56.5x43x41.5	56.5x43x41.5	70x46.5x68.5
weight	about240g	about120g	about240g	about120g	about120g	about240g

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Contact Info

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Address

No. 578 Yingkou Road, Yangpu District, Shanghai, China
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Tel

+86-021-56729166
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E-mail

tom.he@shbojiong.com

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